Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways

MacLean MR, Walker OL, Arun RP, Fernando W, Marcato P (2024) Informed by cancer stem cells of solid tumors: Advances in treatments targeting tumor-promoting factors and pathways. Int J Mol Sci 25(7):4102. doi: 10.3390/ijms25074102 PMID: 38612911

Objective: To provide a comprehensive overview of the therapeutic targets associated with cancer stem cells (CSCs) of solid tumors across various cancer types, including key molecular markers aldehyde dehydrogenases, CD44, epithelial cellular adhesion molecule, and CD133 and signaling pathways such as Wnt/β-catenin, Notch, and Sonic Hedgehog.

Summary: Notably, many of the molecular targets and pathways associated with CSCs are also expressed in normal physiological processes and other stem cell populations. This presents a significant hurdle, as on-target effects of therapeutic interventions could inadvertently impact normal tissue function, leading to potential toxicity and adverse effects.

Usage: Bostad et al. used photochemical internalization to deliver Anti-CD133-SAP (IT-82) to WiDr colon cancer tumor-bearing mice, resulting in a significant decrease in tumor growth compared to control.

Related Products: Anti-CD133-SAP (Cat. #IT-82)

See Also:

• Bostad M et al. Light-controlled endosomal escape of the novel CD133-targeting immunotoxin AC133-saporin by photochemical internalization – A minimally invasive cancer stem cell-targeting strategy. J Control Release 206:37-48, 2015.