Riccardi F, Tangredi C, Dal Bo M, Toffoli G (2024) Targeted therapy for multiple myeloma: an overview on CD138-based strategies. Front Oncol 14:1370854. doi: 10.3389/fonc.2024.1370854 PMID: 38655136
Objective: To provide an overview of the most important aspects of multiple myeloma (MM) disease and to investigate the molecular functions of CD138 in physiologic and malignant cell states.
Summary: CD138 has been detected as one of the most important antigens characterizing the surface of MM cells. Although most CD138-targeting strategies have shown promising results in in vitro and/or ex vivo cells and in mouse models, there are still some caveats and limitations that need to be carefully considered, especially in terms of mechanism of action and safety.
Usage: In MM, immunotoxins have been constructed from B-B2 and B-B4 mAbs by coupling them to the plant ribosome inactivating protein saporin (PR-01), resulting in a significant reduction in the number of plasma cells (PCs).
Related Products: Saporin (Cat. #PR-01)
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