Malley KM, Ruiz AD, Darrow MJ, Danaphongse TT, Shiers S, Ahmad FN, Mota Beltran C, Stanislav BT, Rennaker II RL, Kilgard MP, Hays SA (2023) Neural mechanisms responsible for vagus nerve stimulation-dependent enhancement of somatosensory recovery. SSRN doi: 10.2139/ssrn.4662058
Objective: Optimizing and identifying mechanism of curative action in Vagus Nerve Stimulation therapy on a model of somatosensory deficiency.
Summary: Vagus Nerve Stimulation (VNS) offers promise as a means to treat impairments in somatosensory function after a nerve injury. In a model of chronic sensory loss, VNS of moderate intensity was found to be the most therapeutic. VNS treatment mechanisms were found through models of cholinergic deficits created by 192-IgG-SAP.
Usage: Lesions to the nucleus basalis of rats were made with 192-IgG-SAP [IT-01] (0.375 mg/mL in saline).
Related Products: 192-IgG-SAP (Cat. #IT-01)