Silva JDN, Oliveira LM, Souza FC, Moreira TS, Takakura AC (2020) GABAergic neurons of the medullary raphe regulate active expiration during hypercapnia. J Neurophysiol 123(5):1933-1943. doi: 0.1152/jn.00698.2019 PMID: 32267190
Objective: To test the hypothesis that the medullary raphe, a region known to be involved in breathing, also contributes to expiratory activity under hypercapnic conditions.
Summary: Depletion of serotonergic neurons with Anti-SERT-SAP (IT-23) injections into raphe obscurus (ROb) and magnus (RMg) did not increase the amplitude of abdominal activity during hypercapnia. These results show that the presumably GABAergic neurons within the RMg and ROb may be the inhibitory source to modulate the activity of the parafacial respiratory group during hypercapnia condition.
Usage: Intraparenchymal injections of Anti-SERT-SAP (IT-23) were injected into ROb or RMg at (10 µg/µl).
Related Products: Anti-SERT-SAP (Cat. #IT-23)