Pandala N, Han I, Meyering E, Stone EM, Mullins RF, Tucker BA (2024) iPSC derived choroidal endothelial cell delivery using laminin-based hydrogels for the treatment of AMD. ARVO Annual Meeting 65(7):1542.
Objective: To demonstrate an interventional therapy for age-related macular degeneration (AMD) using a rat model.
Summary: In this study, induced pluripotent stem cells (iPSCs) were injected into the eyes of rats that had undergone Anti-CD105-SAP-induced choroidal cell death, mimicking the pathology of AMD. The efficacy of the iPSC treatment was evaluated by comparing donor cell survival, retention, and integration in treated eyes versus controls that did not receive iPSCs.
Usage: Anti-CD105-SAP (IT-80) was administered via supra-choroidal injection at a concentration of 0.05 mg/ml to selectively induce choroidal endothelial cell death.
Related Products: Anti-CD105-SAP (Cat. #IT-80)