Ramezani F, Salehian S, Hosseinzadeh S, Mahjour Z, Babajani T, Ghorbanian D, Feizi F, Pourbagher R (2022) Serotonin-1A receptor activation in the median raphe nucleus improves response learning-based strategy in 192IgG saporin-induced cognitive impairments. Eur J Pharmacol 918:174774. doi: 10.1016/j.ejphar.2022.174774 PMID: 35077674
Objective: Study the effects of median raphe nucleus serotonin-1A autoreceptors stimulation on rats.
Summary: Rats treated with 192-IgG-SAP were put into a Morris maze and studied for spatial cognition. Treated rats offered a proxy for cognitive impairment that directly mimics some features of neurodegeneration in Alzheimer’s disease. Results strongly suggest the involvement of the serotonergic system in spatial navigation.
Usage: Selective cholinergic denervation was achieved by intra-cerebroventricular administration of the 192-IgG-SAP (1.0 μl/each ventricle at the rate of 0.2 μl/min ) on male Wistar rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)