Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies

Abdolvahab MH, Karimi P, Mohajeri N, Abedini M, Zare H (2024) Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: The most attractive application of nanobodies. Cancer Cell Int 24(1):67. doi: 10.1186/s12935-024-03259-8 PMID: 38341580

Objective: Using nanobodies to deliver saporin to breast cancer cells.

Summary: Through the binding of saporin to a nanobody, a fragment of an antibody, breast cancer cells that over-express Her2 can be targeted and eliminated. Binding of saporin in nanoparticles to 11A4 nanobody (anti-HER2 receptor) showed dose-dependent cytotoxicity against SK-BR-3 cells when tested. Photochemical internalization of saporin loaded nanoparticles also demonstrated dose-dependent cytotoxicty in SK-BR-3 breast cancer cells.

Related Products: Trastuzumab (Anti-HER2)-SAP (Cat. #BETA-038)

See Also:

• Martínez-Jothar L, Beztsinna N, van Nostrum CF, Hennink WE, Oliveira S (2019) Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination with Photochemical Internalization. Mol Pharm 16(4):1633-1647. doi: 10.1021/acs.molpharmaceut.8b01318 PMID: 30817164