Gandek TB, van der Koog L, Nagelkerke A (2023) A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles. Adv Healthc Mater 12(25):e2300319. doi: 10.1002/adhm.202300319 PMID: 37384827
Objective: Using peptide-functionalized extracellular vesicles (EVs), filled with saporin, to increase cytotoxicity over normal biological EVs.
Summary: Extracellular vesicles were used as a means to deliver saporin to HeLa and CHO-K1 cells. Octaarginine peptides (R8 peptides) are seeded on the surface of the EVs which enhanced the macropinocytotic uptake and internalization efficiency as compared to unmodified EVs.
Usage: Saporin was packaged in extracellular vesicles with R8 pepetides and treated on HeLa (Nakase, 2016) and CHO-K1 cells (Nakase, 2017).
Related Products: Saporin (Cat. #PR-01)
See Also: