Moreno-Rodríguez M, Martínez-Gardeazabal J, Bengoetxea de Tena I, Llorente-Ovejero A, Lombardero L, González de San Román E, Giménez-Llort L, Manuel I, Rodríguez-Puertas R (2024) Cortical lipids containing choline mediate cannabinoid-induced cognitive improvement. bioRxiv 2024.03.07.583670. doi: 10.1101/2024.03.07.583670
Objective: Investigate the neuroprotective effect of treatment with the CB1 cannabinoid agonist, WIN55,212-2, against cholinergic degeneration.
Summary: The endocannabinoid (eCB) system plays a role in modulating learning and memory processes controlled by cholinergic neurotransmission. The authors propose that activation of this system is neuroprotective against cholinergic degeneration, such as what occurs in Alzheimer’s disease (AD). In a 192-IgG-SAP (Cat. IT-01) induced model of AD, a restoration of memory and learning was observed when rats were administered the CB1 cannabinoid agonist, WIN55,212-2.
Usage: Rats received injections of 192-IgG-saporin (130 ng/µl) into the nucleus basalis magnocellularis.
Related Products: 192-IgG-SAP (Cat. #IT-01)