Li Y, Champion JA (2022) Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery. Adv Drug Deliv Rev 189:114462. doi: 10.1016/j.addr.2022.114462 PMID: 35934126
Objective: Review recent advances in protein nano-carriers that are from ground-up design recombinant proteins.
Summary: Nanocarriers with a size range of 10-200 nm have emerged as platforms with significant potential for efficient drug delivery via a wide variety of administration routes. To develop nanocarriers for drug delivery, the following functionalities should be achieved. Nanocarriers encapsulate drugs with high loading efficiency and maintain stability in vivo to protect drugs from degradation and prolonged in vivo circulation in blood or residence time in other tissues help improve the fraction of drug-loaded nanocarriers that reach the target site or cells. The Design functionalization, and therapeutic application of protein nanocarriers will be reviewed.
Usage: Saporin is used as the molecular cargo for Protein-Glycan Nanocarriers.
Related Products: Saporin (Cat. #PR-01)