Sun Z, Huang J, Fishelson Z, Wang C, Zhang S (2023) Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress. Biomedicines 11(7):1971.
Objective: Review the development process of cell penetrating peptides and summarize the composition and classification of the penetrating peptide-based delivery systems, cellular uptake mechanisms, influencing factors, and biological barriers.
Summary: Delivery of macromolecular drugs (like saporin) with a cell penetrating peptide can be an effective way to create bioavailability. The principle underlying these approaches is to briefly destroy the cell membrane so that macromolecular drugs can enter the cell, after which the cell membrane is repaired and can restore cell homeostasis. Compared to other methods, the use of Cell Penetrating Peptides causes less damage to the cell membrane and is more effective and safe offering itself as a useful tool for macromolecular drug delivery.
Usage: Saporin as a conjugate to cell penetrating peptides. Nakase (2016) uses Saporin as a part of an extracellular vesicle conjugated with octaarginine, a cell penetrating peptide.
Related Products: Saporin (Cat. #PR-01)
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