Yang WH, Cheng CY, Chen MF, Wang TC (2018) Cell subpopulations overexpressing p75NTR have tumor-initiating properties in the c6 glioma cell line. 38(9):5183-5192. doi: 10.21873/anticanres.12841 PMID: 30194166
Objective: This study is focused on the possible role of p75NTR in glioma tumor initiation.
Summary: Cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such as neurosphere formation, high colony proliferation, and resistance to radio- and chemotherapy. With regard to the heterogeneous composition of glioma cells, p75NTR can be used as an alternative marker to identify a glioma subpopulation with tumor-initiating properties.
Usage: flow cytometry
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