McNamara M (2019) Development of novel therapies for marfan syndrome using a human iPSC-disease model. University of Cambridge Thesis. doi: 10.17863/CAM.38053
Objective: To address different strategies that could potentially be developed into treatments of Marfan Syndrome (MFS) for the clinic.
Summary: Preliminary results show that their disease model exhibits reduced GSK3β protein expression despite GSK3β inhibition proving to be beneficial in restoring some of the phenotypic features. Further experimental efforts need to be effectuated to harness precisely the GSK3β-dependent signaling pathways that govern the phenotypic abnormalities and characterize their MFS disease model.
Usage: immunocytochemistry (1:500)
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