Huang WC (2016) Stem cells in tissue regeneration and diseases. University of California, Berkeley Thesis.
Objective: To investigate the therapeutic effect of induced pluripotent stem cell-derived neural crest stem cells (iPSC-NCSCs) and mesenchymal progenitor cells (MPCs) on peripheral nerve regeneration.
Summary: Transplantation of NCSCs has better outcomes of motor nerve recovery and muscle reinnervation by Schwann cell differentiation in vivo and paracrine signaling, whereas transplantation of MPCs fails to promote functional nerve regeneration.
Usage: Immunostaining to characterize MPCs
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