Pereira PM, Papy-Garcia D, Barritault D, Chiappini F, Jackisch R, Schimchowitsch S, Cassel JC (2022) Protective Effects of a synthetic glycosaminoglycan mimetic (OTR4132) in a rat immunotoxic lesion model of septohippocampal cholinergic degeneration. Glycoconj J 39(1):107-130. doi: 10.1007/s10719-022-10047-x PMID: 35254602
Objective: Assess the effects of OTR4132, a synthetic heparan-mimetic biopolymer that is designed to have neuroprotective/neurotrophic properties.
Summary: 192-IgG-SAP was used to create a partial hippocampal cholinergic denervation model. Rats were also injected with OTR4132, either intramuscularly (1.5 mg/kg) or into the lateral ventricle (0.25ug/5 ul/rat). Rats injected with 192-IgG-SAP showed decreases in (1) hippocampal acetylcholinesterase reaction products and in (2) choline acetyltransferase-positive neurons in the medial septum. Both these attributes were significantly lessened in rats treated with OTR4132.
Usage: 192-IgG-SAP was injected into the medial septum/diagonal band of broca (0.37 ug) of Long-Evans male rats.
Related Products: 192-IgG-SAP (Cat. #IT-01)