Ebadi R, Rabiee F, Kordi-Tamandani D, Nasr-Esfahani MH, Ghaedi K (2021) Fndc5 knockdown significantly decreased the expression of neurotrophins and their respective receptors during neural differentiation of mouse embryonic stem cells. Hum Cell 34(3):847-861. doi: 10.1007/s13577-021-00517-z PMID: 33683654
Objective: To evaluate whether knockdown of Fibronectin type III domain-containing-5 (Fndc5) decreases neural differentiation of mouse embryonic stem cells (mESCs) by affecting the neurotrophins and their receptor expression.
Summary: Results suggest that decreased efficiency of neural differentiation following the reduction of Fndc5 expression could be attributed to decreased levels of NGF and BDNF proteins in addition to their cognate receptors.
Usage: Western blot (1:4000)
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