Cui YH, Zhou SF, Liu Y, Wang S, Li F, Dai RP, Hu ZL, Li CQ (2021) Injection of anti-proBDNF attenuates hippocampal-dependent learning and memory dysfunction in mice with sepsis-associated encephalopathy. Front Neurosci 15:665757. doi: 10.3389/fnins.2021.665757 PMID: 34354558
Objective: To study the effects and associated mechanism of hippocampal proBDNF in a lipopolysaccharide (LPS)-induced sepsis-associated encephalopathy (SAE) mouse model.
Summary: Mice showed cognitive dysfunction after LPS injection. The expression of proBDNF and its receptor, p75NTR, was increased in the hippocampus. The levels of BDNF and its receptor, TrkB, were decreased. An intrahippocampal or intraperitoneal injection of anti-proBDNF antibody ameliorated LPS-induced cognitive dysfunction.
Usage: Western blot (1:1000)
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)