Waite JJ, Wardlow ML, Power AE (1999) Deficit in selective and divided attention associated with cholinergic basal forebrain immunotoxic lesion produced by 192-Saporin; motoric/sensory deficit associated with Purkinje cell immunotoxic lesion produced by OX7-Saporin. Neurobiol Learn Mem 71(3):325-352. doi: 10.1006/nlme.1998.3884
Objective: To distinguish behavioral effects of 192-IgG-SAP due to cerebellar damage versus those due to cholinergic cell loss.
Summary: The cholinergic basal forebrain lesion may mask some of the effects of cerebellar damage up to a threshold after which effects of Purkinje cell loss predominate when 192-IgG-SAP is administered intraventricularly.
Usage: 192-IgG-SAP (1.6, 2.6, and 3.3 ug/rat) and OX7-SAP (2.0 ug/rat) were administered by bilateral icv infusions (5 ul vol/side).
Related Products: 192-IgG-SAP (Cat. #IT-01), OX7-SAP (Cat. #IT-02)