Nurmasitoh T, Sari DCR, Susilowati R (2021) Toxic substance-induced hippocampal neurodegeneration in rodents as model of Alzheimer’s dementia. Open Access Maced J Med Sci [Internet] 9(F):523.
Summary: In this review, the authors discussed hippocampal neurodegeneration rodent animal models of Alzheimer’s Dementia and their induction via a toxic substance. Between 2016-2021, 80 studies were reported with 17 different modeling techniques mentioned.
Usage: 192-IgG-Saporin was referenced using intracerebroventricular injection (ICV) as the route of administration where the parameters studied included, neurotrophic factors, cholinergic activity and neuro-degeneration markers.
Related Products: 192-IgG-SAP (Cat. #IT-01)
See Also:
- Gelfo F et al. Chronic lithium treatment in a rat model of basal forebrain cholinergic depletion: Effects on memory impairment and neurodegeneration. J Alzheimers Dis 56:1505-1518, 2017.
- Volobueva MN et al. Intracerebroventricular administration of 192IgG-saporin alters the state of microglia in the neocortex. Neurochem J 14(1):37-42, 2020.
- Shin J et al. Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model. Alzheimers Res Ther 11(1):110, 2019.