Chen X, Liu H, Li A, Ji S, Fei H (2021) Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides. J Biol Chem 297(6):101364. doi: 10.1016/j.jbc.2021.101364
Objective: The study focuses on hydrophobicity and a structure-function strategy to evolve a template peptide for endosomolytic cargo delivery.
Summary: The peptide LP6 could dramatically promote cargo cell entry and facilitate cytosolic delivery of biomacromolecules such as saporin.
Usage: HeLa cells were treated with saporin (10, 20, 50μg/ml) in the absence (–) or presence (+) of LP6 (20μM) to confirm the cytosolic delivery ability of LP6.
Related Products: Saporin (Cat. #PR-01)