Dalley JW, Cardinal RN, Robbins TW (2004) Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates. Neurosci Biobehav Rev 28(7):771-784. doi: 10.1016/j.neubiorev.2004.09.006
Objective: To review current progress in our understanding of the rodent prefrontal cortex, especially evidence for functional divergence of the anatomically distinct sub-regions of the rat prefrontal cortex.
Summary: A greater understanding of the prefrontal cortex will come from using tasks that load specific cognitive and executive processes, in parallel with discovering new ways of manipulating the different sub-regions and neuromodulatory systems of the prefrontal cortex.
Usage: Lesions of the cortically projecting cholinergic neurons of the nucleus basalis magnocellularis made using excitotoxins, or the highly selective cholinergic immunotoxin 192 IgG-SAP, generally impair discriminative performance.
Related Products: 192-IgG-SAP (Cat. #IT-01)