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The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?

Hasegawa H, Selway R, Gnoni V, Beniczky S, Williams SCR, Kryger M, Ferini-Strambi L, Goadsby P, Leschziner GD, Ashkan K, Rosenzweig I (2020) The subcortical belly of sleep: New possibilities in neuromodulation of basal ganglia?. Sleep Med Rev 52:101317. doi: 10.1016/j.smrv.2020.101317

Summary: Complete BF lesion with OX-SAP leads to coma-like state and flat EEG, reduced Fos in cerebral cortex (but high Fos in brainstem, thalamus, hypothalamus) selective (cholinergic or non-cholinergic) lesion does not have this effect.

Usage: Lesions of the basal forebrain were done by injecting a 0.1% solution of Orexin-SAP at four different sites.

See: Fuller P et al. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol 519(5):933-956, 2011.

Related Products: Orexin-B-SAP (Cat. #IT-20)