Gu Z, Yu J, Werrbach-Perez K, Perez-Polo JR (2000) Repeated immunolesions display diminished stress response signal. Int J Dev Neurosci 18:177-183. doi: 10.1016/s0736-5748(99)00086-6
Summary: Cholinergic neurons in the basal forebrain are involved in neurotrophin release in general injury response although this response is impaired in the aged individual. Addition of pharmacological doses of NGF can repair this mechanism. Gu et al. used 192-Saporin (Cat. #IT-01) to model the endogenous stimulation of NGF in response to injury. They found that a one-time administration of 192-Saporin was more effective than chronic repeated administrations for inducing an increase in NGF levels. These results indicate that chronic lesions may cause a desensitization that differs from the acute toxic model.
Related Products: 192-IgG-SAP (Cat. #IT-01)