Fitz NF, Li P, Johnson DA (2004) Effects of dehydroepiandrosterone sulfate on delayed match to position T-maze task performance in 192- IgG saporin lesioned rats. Neuroscience 2004 Abstracts 436.2. Society for Neuroscience, San Diego, CA.
Summary: Prior studies have shown that infusion of 192 IgG-saporin (SAP), a cholinergic neurotoxin, into the media septum (MS) of rats selectively lesions cholinergic neurons that project to the hippocampus, resulting in impaired acquisition of a delayed matching to position (DMP) T-maze task. Since the neurosteriod dehydroepiandrosterone sulfate (DHEAS), displayed memory enhancing properties in rodents, the present study investigated the effects of DHEAS administration on MS SAP lesioned animals. Male Sprague-Dawley rats received intraseptal infusions of either cerebrospinal fluid or SAP (0.22 μg/μl). Fourteen days later, the rats were administered IP injections of either DHEAS (20mg/ml) or vehicle one hour prior to DMP testing. During the acquisition phase of testing, each rat completed 8 trial pairs per day until reaching criterion (15 of 16 correct choices). Treatment with DHEAS resulted in a 10% shortening of the number of days to reach criterion in the SAP treated animals compared to SAP non-treated animals.
Related Products: 192-IgG-SAP (Cat. #IT-01)