Linster C, Garcia PA, Hasselmo ME, Baxter MG (2001) Selective loss of cholinergic neurons projecting to the olfactory system increases perceptual generalization between similar, but not dissimilar, odorants. Behav Neurosci 115(4):826-833. doi: 10.1037//0735-7044.115.4.826
Summary: Selective cholinergic lesioning of the basal forebrain has been linked to attentional and cognitive deficits. 192-Saporin (Cat. #IT-01) was administered to the horizontal limb of the diagonal band of Broca (0.3 µl at 0.175 µg/µl in each hemisphere) destroying projections to the olfactory bulb and cortex. The results demonstrate cholinergic lesions affect the perceptual qualities of odors, and may possibly represent a general mechanism for cholinergic effects on information processing.
Related Products: 192-IgG-SAP (Cat. #IT-01)