Harrell LE, Parsons D, Kolasa K (2001) Hippocampal sympathetic ingrowth occurs following 192-IgG-saporin administration. Brain Res 911:158-162. doi: 10.1016/s0006-8993(01)02626-9
Summary: Electrolytic lesions of the medial septal region in rats cause peripheral sympathetic fibers from the superior cervical ganglia to grow into the cholinergically-denervated areas of the hippocampus. This lesioning method is non-specific and disrupts several other cell types in the area of the lesion. The authors infused 192-Saporin (1 µg/10 µl saline into medial septum; Cat. #IT-01) to eliminate only the cholinergic neurons, leaving other cell types intact. Hippocampal sympathetic ingrowth still occurs when only the cholinergic neurons are eliminated, indicating that this occurrence is in response to the loss of cholinergic projections from the medial septum.
Related Products: 192-IgG-SAP (Cat. #IT-01)