Jeong D, Hwang Y, Chang J (2008) The effect of electrical stimulation in the rats for dementia animal model. Neuroscience 2008 Abstracts 340.11/M2. Society for Neuroscience, Washington, DC.
Summary: Forebrain Cholinergic neurons in the nucleus basalis meynert (NBM) project primarily to the neocortex, and those in the medial septum project to the hippocampus and make a role in memory function. A case study was reported that electrical stimulation of the hypothalamus improves hippocampus dependent memory function. The hypothesis of this study is that electrical stimulation of NBM would induce memory enhancement by effect on neocortex and/or hippocampus. Animal models were induced by selective immunolesion of cholinergic neurons. The cholinergic immunotoxin 192 IgG-saporin was injected in lateral ventricle. 192 IgG-saporin injected rats were compared with Dulbecco’s phosphate bufferd saline (DPBS) injected rats. Neurological deficit and functional outcome were determined by immuohistochemistry using anti-choline acetyl transferase antibody and Morris water maze behavioral test. DBS electrode was implanted in NBM and Stimulation parameters are selected from animal stimulation test. Extent of the cholinergic lesion was showed in the basal forebrain complex region at 192 IgG-saporin injected rats. 192 IgG-saporin injected rats were severely impaired in the probe test of the water maze test. We observe that NBM stimulation induced memory enhancement in dementia models through the behavioral test. Therefore, our animal DBS system could be a useful instrument for investigation of dementia.
Related Products: 192-IgG-SAP (Cat. #IT-01)