Tapp D, McMurray M (2017) Serotoninergic projections to the OFC and BLA modulate reversal learning. Neuroscience 2017 Abstracts 423.01 / TT12. Society for Neuroscience, Washington, DC.
Summary: Behavioral ﬂexibility, the ability to adapt to changing reward contingencies, is a critical aspect of choice behavior. Such ability is disrupted in numerous psychiatric disorders, such as substance abuse disorders, attention deﬁcit disorder, and obsessive- compulsive disorder. The orbitofrontal cortex (OFC) and the basolateral amygdala (BLA) have been implicated as key regulators for this behavior. Additionally, the neurotransmitter serotonin is known to inﬂuence behavioral ﬂexibility, and is disrupted in numerous psychiatric disorders. While serotonin and these brain regions have been examined separately, they have yet to be directly linked in this behavioral context. Using a rat model, this study examined such a relationship by selectively leisoning serotoninergic projections to the OFC, BLA, or both regions with a SERT-conjugated Saporin, and assessing behavioral ﬂexibility in a probabilistic spatial reversal-learning task. Preliminary results indicated that the loss of serotonergic projections to either the OFC, BLA, or both impaired behavioral ﬂexibility. Based on these results, we determined that serotonin regulates reversal learning through its action in the OFC and BLA. Therefore, the serotonergic system may serve as a future therapeutic target for diseases in which behavioral ﬂexibility is impaired, and may explain the eﬀectiveness of serotonin modulators in the treatment of these diseases.
Related Products: Anti-SERT-SAP (Cat. #IT-23)