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Selective loss of septohippocampal cholinergic projections is associated with more circuitous homeward progressions

Osterlund JR, BLackwell AA, Lipton M, Castillo V, Kartje GL, Tsai S-Y, Wallace DG (2019) Selective loss of septohippocampal cholinergic projections is associated with more circuitous homeward progressions. Neuroscience 2019 Abstracts 789.11. Society for Neuroscience, Chicago, IL.

Summary: Rodents rely on self-movement cues as a source of information to maintain spatial orientation during exploration. The vestibular system provides a source of self-movement cues that are processed by the septohippocampal cholinergic system, and when damaged, disruptions in movement organization are observed. The current study examined the effects of medial septum infusion of 192 IgG-saporin on movement organization during a single exploratory session that limited rats to using only self-movement cues. Rats organize their exploratory behavior into stops and progression. Although stops occur throughout the environment, they tend to cluster within a restricted area indicative of home base establishment. In the current study, movement organization characteristics and home base stability were similar between the lesion and sham groups. However, the lesion group exhibited greater path circuity during progressions returning to the home base. Increases in path circuitry have been implicated in spatial disorientation, indicating a role for medial septum cholinergic projections in processing self-movement cues to maintain spatial orientation. These results provide a foundation for future work to investigate the efficacy of interventions that enhance neuroplasticity within the septohippocampal cholinergic system.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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