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Coiled coil-based therapeutics and drug delivery systems

Utterström J, Naeimipour S, Selegård R, Aili D (2021) Coiled coil-based therapeutics and drug delivery systems. Adv Drug Deliv Rev 170:26-43. doi: 10.1016/j.addr.2020.12.012

Summary: Coiled coils are abundant structural motifs found in many fibrous proteins and transcription factors and are often involved in assembly of higher order protein structures. The possibilities to use coiled coil as key molecular components in drug delivery systems, biomaterials, vaccines and therapeutics can be further expanded by combining them with other proteins as fusion proteins or synthetic polymers, proteins, carbohydrates, lipids and inorganic nanoparticles, using physical interactions or chemical conjugation, to create coiled coil hybrids and nanocomposites. The possibility to deliver drugs was evaluated by loading the highly potent protein toxin saporin (SAP) in the nanogels, resulting in a significant decrease in viability of MCF-7 breast cancer cells.

Related Products: Saporin (Cat. #PR-01)