1. Home
  2. Knowledge Base
  3. References
  4. Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.

Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.

Akahoshi N, Kamata S, Kubota M, Hishiki T, Nagahata Y, Matsuura T, Yamazaki C, Yoshida Y, Yamada H, Ishizaki Y, Suematsu M, Kasahara T, Ishii I (2014) Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria. Am J Physiol Renal Physiol 306:F1462-1476. doi: 10.1152/ajprenal.00623.2013

Summary: The authors utilized a mouse model for homocystinuria in order to examine renal amino acid reabsorbtion. Some of the immunohistochemistry experiments used anti-Met (Cat. #AB-T036). It was found that loss of cystathionine β-synthase causes hyperexcretion of both glucogenic and ketogenic neutral amino acids, as well as histidine.

Related Products: Anti-Conjugated Methionine (Cat. #AB-T036)