Ostock C, Lindenbach D, Goldenberg A, Kampton E, Bishop C (2014) Effects of noradrenergic denervation by anti-DBH-saporin on behavioral responsivity to L-DOPA in the hemi-parkinsonian rat. Behav Brain Res 270:75-85. doi: 10.1016/j.bbr.2014.05.009 PMID: 24837745
Objective: To study the effects of L-DOPA treatment on a Parkinson’s model of rats, particularly regarding noradrenergic denervation of the locus coeruleus.
Summary: L-DOPA is the most effective treatment against Parkinson’s disease. There are, however, significant side effects like L-DOPA-induced Dyskinesias (LID) that are overlooked. This study uses 6-OHDA + Anti-DBH-SAP lesioned rats to induce Parkinson’s-like behavior and monitor LID throughout treatment with L-DOPA.
Usage: 10 µg of Anti-DBH-SAP injected into the nigral neurons of the brains of rats.
Related Products: Anti-DBH-SAP (Cat. #IT-03)