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Lacrimal gland denervation alters tear protein composition and impairs ipsilateral eye closures and corneal nociception

Hegarty DM, David LL, Aicher SA (2018) Lacrimal gland denervation alters tear protein composition and impairs ipsilateral eye closures and corneal nociception. Invest Ophthalmol Vis Sci 59:5217-5224. doi: 10.1167/iovs.18-25267

Objective: To evaluate spontaneous and evoked ocular sensory responses in rats after denervation of the lacrimal gland, as well as protein changes in tears that may mediate functional changes.

Summary: Denervation of the lacrimal gland causes long-lasting hypoalgesia, impairs the blink response, and alters tear proteins.

Usage: 192-IgG-SAP (5 μL, 0.5 μg/μL) was microinjected into the left extraorbital lacrimal gland. In a separate group, 192-IgG-SAP was applied directly and unilaterally to the corneal surface.

Related Products: 192-IgG-SAP (Cat. #IT-01)