McHugh S, Francis A, McAuley J, Stewart A, Baxter M, Bannerman D (2015) Hippocampal acetylcholine depletion has no effect on anxiety, spatial novelty preference, or differential reward for low rates of responding (DRL) performance in rats. Behav Neurosci 129:491-501. doi: 10.1037/bne0000072
Summary: It is unclear whether cholinergic lesions in the hippocampus affect both learning and behavior, or learning only. In this study the authors lesioned cholinergic neurons in the medial septum/vertical limb of the diagonal band of Broca of rats with bilateral 30-ng injections of 192-IgG-SAP (Cat. #IT-01). Although hippocampal cholinergic innervations were significantly reduced, with a concomitant reduction in choline acetyltransferase activity, the lesioned animals did not perform differently in several behavioral tests. The data do not provide evidence that the septo-hippocampal cholingeric projections play a role in anxiety, spatial novelty preference, or differential reward for low rates of responding tests.
Related Products: 192-IgG-SAP (Cat. #IT-01)