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  4. Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex.

Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex.

Urquhart MA, Ross JA, Reyes BAS, Nitikman M, Thomas SA, Mackie K, Van Bockstaele EJ (2019) Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex. Neurobiology of Stress 10:100164. doi: 10.1016/j.ynstr.2019.100164

Objective: To determine the effects of NE depletion on the eCB system.

Summary: The results suggest that the endocannabinoids (eCB) system may be more responsive in males than females under conditions of NE perturbation, thus having potential implications for sex-specific treatment strategies of stress-related psychiatric disorders.

Usage: The authors used a DBH knockout model and DSP-4 (a compound that depletes endogenous norepinephrine and enhances release of [3H]norepinephrine). More specific mechanisms for further corroboration could be undertaken, such as using Anti-DBH-SAP to provide a more complete lesion compared to DSP-4.

Related Products: Anti-DBH-SAP (Cat. #IT-03)