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Effect of placenta-derived mesenchymal stem cells in a dementia rat model via microglial mediation: A comparison between stem cell transplant methods

Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW (2018) Effect of placenta-derived mesenchymal stem cells in a dementia rat model via microglial mediation: A comparison between stem cell transplant methods. Yonsei Med J 59:406-415. doi: 10.3349/ymj.2018.59.3.406

Objective: To study the therapeutic effects of human placenta-derived mesenchymal stem cells (pMSCs) in a dementia rat model using either intracerebroventricular (ICV) or intravenous (IV) injections and analyze their mechanisms of therapeutic action.

Summary: ICV and IV injections of pMSCs facilitate the recovery of cholinergic neuronal populations and cognitive behavior. This recovery likely occurs through paracrine effects that resemble microglia function rather than direct differentiation of injected pMSCs into cholinergic neurons.

Usage: Dementia modeling was established by bilateral ventricle infusion of 192 IgG-SAP to lesion cholinergic neurons. 8 μL of 192 IgG-saporin (0.63 μg/μL) were bilaterally injected into the lateral ventricle at a rate of 1 μL/min and was left to diffuse for 5 min after injection. Rats were subjected to the Morris water maze and subsequent immunostaining analyses.

Related Products: 192-IgG-SAP (Cat. #IT-01)