Watanabe T, Ito T, Inoue G, Ohtori S, Kitajo K, Doya H, Takahashi K, Yamashita T (2008) The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res 86:3566-3574. doi: 10.1002/jnr.21808 PMID: 18709654
Summary: Inflammation, which can lead to pain hypersensitivity, not only elevates NGF levels, but also can increase the sensitivity of high-threshold receptors. NGF is thought to be a major contributor to heightened pain states due to inflammation, and in this work the authors investigated the role that the p75 neurotrophin receptor might play in NGF-induced hyperalgesia. 30 minutes prior to injection with Freund’s adjuvant, mice received 10 μl of polyclonal anti-p75 (Cat. #AB-N01) into the plantar surface of the paw. The antibody administration blocked hyperalgesia, indicating that p75 plays an important role in inflammation-induced hyperalgesia.
Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)