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Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze.

Jeong D, Lee J, Chang W, Chang J (2017) Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze. BMC Neuroscience 18:29.. doi: 10.1186/s12868-017-0345-4

Summary: This study was performed to determine the stage of memory affected by medial septum deep brain stimulation (MS-DBS). Memory impairment due to cholinergic denervation can be improved by DBS. The improvement is significantly correlated with the up-regulation of BDNF expression and neurogenesis. Based on the results of this study, the use of MS-DBS during the early stage of disease may restore spatial memory impairment.

Usage: Rats were injected bilaterally with 8 μl of 192-IgG-SAP (0.63 μg/μl) at the cerebroventricle.

Related Products: 192-IgG-SAP (Cat. #IT-01)

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