Steiner J, Carneiro A, Wright J, Matthies H, Prasad H, Nicki C, Dostmann W, Buchanan C, Corbin J, Francis S, Blakely R (2009) cGMP-dependent protein kinase Ialpha associates with the antidepressant-sensitive serotonin transporter and dictates rapid modulation of serotonin uptake. Mol Brain 2:26. doi: 10.1186/1756-6606-2-26 PMID: 19656393
Summary: The neurotransmitter serotonin fulfills an important modulatory role in a wide range of brain functions including mood, appetite, sexual behavior, and reward. Serotonin transporters (SERT) are involved in the inactivation of synaptic serotonin, as well as serotonin recycling, which is critical to the maintenance of neuronal serotonin stores. In this work the authors examined how neuronal A3 adenosine receptor activation can enhance presynaptic serotonin transport in vitro as well as SERT-mediated clearance in vivo. The in vitro experiments included immunohistochemistry with anti-SERT (Cat. #AB-N40) on RN46A cells at a 1:500 dilution.
Related Products: SERT Mouse Monoclonal (Cat. #AB-N40)