Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K (2018) The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor. J Neurosci 38:2589-2604. doi: 10.1523/JNEUROSCI.0953-17.2018. PMID: 29440387
Objective: To investigate whether the soluble form of LOTUS (s-LOTUS) also has an inhibitory action on NgR1 function as a candidate for therapeutic agents
Summary: Findings suggest that s-LOTUS inhibits NgR1-mediated signaling possibly by interfering with the interaction between NgR1 and p75NTR. Thus, s-LOTUS may have potential as a therapeutic agent for neuronal regeneration in the damaged CNS
Usage: staining (1:1000)
Related Products: NGFr (mu p75) Rabbit Polyclonal, affinity-purified (Cat. #AB-N01AP)