Wheeler D, Wan S, Miller A, Angeli N, Adileh B, Hu W, Holland P (2014) Role of lateral hypothalamus in two aspects of attention in associative learning. Eur J Neurosci 40:2359-2377. doi: 10.1111/ejn.12592
Summary: The lateral hypothalamic (LH) region contains both orexin and melanin-concentrating hormone (MCH) neurons. These neurons are unique to the LH but project throughout the brain. In this work the authors examined the role of the LH in specific attentional aspects of associative learning. Rats received unilateral 500 ng injections of orexin-SAP (IT-20) into the LH and were tested in several learning tasks. The lesioned animals displayed impaired behavior that was correlated to the loss of orexin but not MCH neurons.
Related Products: Orexin-B-SAP (Cat. #IT-20)