Wan L, Jin H, Liu X, Jeffry J, Barry D, Shen K, Peng J, Liu X, Jin J, Sun Y, Kim R, Meng Q, Mo P, Yin J, Tao A, Bardoni R, Chen Z (2017) Distinct roles of NMB and GRP in itch transmission. Sci Rep 7:15466.. doi: 10.1038/s41598-017-15756-0
Summary: To examine the role of NMBR+ dorsal horn neurons in itch and pain transmission, the authors treated mice with NMB-SAP (Cat. #IT-70; 2–3 μg, i.t.) at which no side effects were observed. NMB-SAP treated mice barely showed scratching behaviors, whereas control mice exhibited NMB-induced scratching with a rapid onset of scratching responses. These data demonstrate an important role of NMBR+ neurons in itch transmission. In contrast to notable deficits in itch transmission, NMB-SAP treated mice exhibited normal behavioral responses to acute mechanical stimuli, thermal stimuli and tail immersion. The authors also examined inflammatory pain behaviors of NMB-SAP treated mice and found normal nocifensive behaviors.
Related Products: NMB-SAP (Cat. #IT-70)