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The M5 cell: A color-opponent intrinsically photosensitive retinal ganglion cell

Stabio ME, Sabbah S, Quattrochi LE, Ilardi MC, Fogerson PM, Leyrer ML, Kim MT, Kim I, Schiel M, Renna JM, Briggman KL, Berson DM (2018) The M5 cell: A color-opponent intrinsically photosensitive retinal ganglion cell. Neuron 97:150-163. doi: 10.1016/j.neuron.2017.11.030

Objective: To provide a fuller description of the least understood ipRGC type, the M5 cell, and discovered a distinctive functional characteristic— chromatic opponency (ultraviolet excitatory, green inhibitory).

Summary: M5 cells send axons to the dLGN and are thus positioned to provide chromatic signals to visual cortex. These findings under- score that melanopsin’s influence extends beyond unconscious reflex functions to encompass cortical vision, perhaps including the perception of color.

Usage: M5 cells have the weakest melanopsin responses of all known ipRGC types. The intrinsic melanopsin response (~10 pA) in M5 cells is at least an order of magnitude smaller than the extrinsic, synaptically mediated response.

Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

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