Stabio ME, Sabbah S, Quattrochi LE, Ilardi MC, Fogerson PM, Leyrer ML, Kim MT, Kim I, Schiel M, Renna JM, Briggman KL, Berson DM (2018) The M5 cell: A color-opponent intrinsically photosensitive retinal ganglion cell. Neuron 97:150-163. doi: 10.1016/j.neuron.2017.11.030 PMID: 29249284
Objective: To provide a fuller description of the least understood ipRGC type, the M5 cell, and discovered a distinctive functional characteristic— chromatic opponency (ultraviolet excitatory, green inhibitory).
Summary: M5 cells send axons to the dLGN and are thus positioned to provide chromatic signals to visual cortex. These findings under- score that melanopsin’s influence extends beyond unconscious reflex functions to encompass cortical vision, perhaps including the perception of color.
Usage: M5 cells have the weakest melanopsin responses of all known ipRGC types. The intrinsic melanopsin response (~10 pA) in M5 cells is at least an order of magnitude smaller than the extrinsic, synaptically mediated response.
Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)