1. Home
  2. Knowledge Base
  3. References
  4. Sonic hedgehog and TDP-43 participate in the spontaneous locomotor recovery in a mouse model of spinal motoneuron disease

Sonic hedgehog and TDP-43 participate in the spontaneous locomotor recovery in a mouse model of spinal motoneuron disease

Gulino R, Parenti R, Gulisano M (2017) Sonic hedgehog and TDP-43 participate in the spontaneous locomotor recovery in a mouse model of spinal motoneuron disease. J Funct Morphol Kinesiol 2:11.. doi: 10.3390/jfmk2020011

Summary: The authors used a mouse model of neurotoxic motoneuron depletion to study the role of Sonic hedgehog and TDP-43 in the compensatory changes occurring after the lesion. The injection of cholera toxin-B saporin (CTB-SAP; Cat. #IT-14) into the gastrocnemius muscle caused a partial motoneuron death accompanied by an impairment of locomotion.  Motor activity was significantly restored as soon as one month later.

Related Products: CTB-SAP (Cat. #IT-14)

Browse Articles

Need Support?

Can't find what you're looking for? Contact us, we're here to help!