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Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.

Douglas AD, Williams AR, Knuepfer E, Illingworth JJ, Furze JM, Crosnier C, Choudhary P, Bustamante LY, Zakutansky SE, Awuah DK, Alanine DG, Theron M, Worth A, Shimkets R, Rayner JC, Holder AA, Wright GJ, Draper SJ (2014) Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5. J Immunol 192(1):245-258. doi: 10.4049/jimmunol.1302045

Summary: Plasmodium falciparum is a protozoan parasite that can cause malaria in humans. The human malaria parasite reticulocyte –binding protein homolog 5 (PfRH5) is a potential target for neutralizing antibodies. PfRH5 binds basigin on erythrocytes, and through the use of anti-basigin (Cat. #AB-42), among other antibodies, the authors better characterized aspects of this binding that may be useful in preventing malaria.

Related Products: Antibody to Basigin (Cat. #AB-42)