Roland JJ, Stewart AL, Janke KL, Gielow MR, Kostek JA, Savage LM, Servatius RJ, Pang KC (2014) Medial septum-diagonal band of Broca (MSDB) GABAergic regulation of hippocampal acetylcholine efflux is dependent on cognitive demands. J Neurosci 34(2):506-514. doi: 10.1523/JNEUROSCI.2352-13.2014
Summary: GABAergic and cholinergic neurons in the medial septum-diagonal band of Broca (MSDB) are both involved with spatial memory. In order to better understand the relationship between these two neuronal populations the authors administered 552.5 ng of GAT-1-SAP (Cat. #IT-32) to the MSDB of rats in several injections. Using a combination of behavioral assays and in vivo microdialysis it was shown that GAT-1-SAP lesions impaired hippocampal acetylcholine efflux as well as performance in the non-matching to position with delay test. The data indicate that GABAergic MSDB neurons are important during high memory load conditions.
Related Products: GAT1-SAP (Cat. #IT-32)