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Depletion of alloreactive T cells by anti-CD137-saporin immunotoxin.

Lee SC, Seo KW, Kim HJ, Kang SW, Choi HJ, Kim A, Kwon BS, Cho HR, Kwon B (2015) Depletion of alloreactive T cells by anti-CD137-saporin immunotoxin. Cell Transplant 24:1167-1181. doi: 10.3727/096368914X679327

Summary: The ability to selectively remove T cells that mediate graft-versus-host disease (GVHD) would prevent graft rejection as well as preserve the T cells that mediate graft-versus-leukemia (GVL) effect – especially in cases of hematopoietic stem cell transplantation. In this work the authors used a custom conjugate of anti-mouse CD137 and saporin to eliminate alloreactive T cells during a T cell donor transfer in mice. Rat IgG-SAP (Cat. #IT-17) was used as a control. Transfer of T cells after the immunotoxin treatment did not cause GVHD, but the GVL effect was left intact, indicating the potential of selective T cell depletion for transplantation.

Related Products: Rat IgG-SAP (Cat. #IT-17)

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