Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJr, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM (2013) Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci 33(8):3633-3645. doi: 10.1523/JNEUROSCI.6390-11.2013
Summary: Pharmacological experiments have suggested that sighs and normal respiration are highly dependent on calcium currents carried by P/Q channels. Using transgenic mice missing the Cav2.1 pore-forming α1A subunit the authors demonstrate that loss of P/Q-type calcium channels results in compromised breathing, sighing, neuromodulation, and leads to early death. A neurokinin-1 receptor antibody (Cat. #AB-N33AP) at a 1:500 dilution was used for immunohistochemistry in this work.
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