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Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels.

Koch H, Zanella S, Elsen GE, Smith L, Doi A, Garcia AJr, Wei AD, Xun R, Kirsch S, Gomez CM, Hevner RF, Ramirez JM (2013) Stable respiratory activity requires both P/Q-type and N-type voltage-gated calcium channels. J Neurosci 33(8):3633-3645. doi: 10.1523/JNEUROSCI.6390-11.2013

Summary: Pharmacological experiments have suggested that sighs and normal respiration are highly dependent on calcium currents carried by P/Q channels. Using transgenic mice missing the Cav2.1 pore-forming α1A subunit the authors demonstrate that loss of P/Q-type calcium channels results in compromised breathing, sighing, neuromodulation, and leads to early death. A neurokinin-1 receptor antibody (Cat. #AB-N33AP) at a 1:500 dilution was used for immunohistochemistry in this work.

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