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Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets.

Leach ND, Nodal FR, Cordery PM, King AJ, Bajo VM (2013) Cortical cholinergic input is required for normal auditory perception and experience-dependent plasticity in adult ferrets. J Neurosci 33(15):6659-6671. doi: 10.1523/JNEUROSCI.5039-12.2013

Summary: In order to study how cholinergic input from the nucleus basalis affects auditory perception and learning, the authors injected a total of 35.2 ng of ME20.4-SAP (Cat. #IT-15) into the nucleus basalis in each hemisphere of ferrets. Based on several learning tasks, the data suggest that these cholinergic inputs aid in the perception of sound source location and aid in the adaptation of the auditory system to changes in spatial cues.

Related Products: ME20.4-SAP (Cat. #IT-15)

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