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  4. Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome.

Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome.

Fiedler J, Strauss G, Wannack M, Schwiebert S, Seidel K, Henning K, Klopocki E, Schmugge M, Gaedicke G, Schulze H (2012) Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome. Haematologica 97(1):73-81. doi: 10.3324/haematol.2011.049619

Summary: Lower than normal blood platelet counts result from a congenital disorder called thrombocytopenia (thrombocytopenia absent radii syndrome, or TAR). Recent work indicates a complex pattern of inheritance, and possibly that TAR is at least a digenic disorder. The authors performed an extended study investigating signal transduction via immunoblotting, gel electrophoretic shift assays, and flow cytometry. One of the antibodies used was anti-p70 S6K (Cat. #AB-241). The authors conclude that there are defects in both platelet production and function in TAR.

Related Products: p70 S6K Rabbit Polyclonal (Cat. #AB-241)